WebbProcainamide works as an anti-arrhythmic agent and is used to treat cardiac arrhythmia. It induces rapid block of the batrachotoxin (BTX)-activated sodium channels of the heart muscle and acts as antagonist to long-gating closures. The block is voltage-dependent and can occur from both sides; either from the intracellular or the extracellular side. WebbIn patients with hepatic disease, lower doses or longer dosing intervals of procainamide may be needed due to reduced procainamide elimination. Procainamide is about 15 to 35% metabolized by N-acetylation, depending on genetic acetylation status.
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Webbquinidine (CYP2D6 inhibitor) 1 interaction. Contraindicated. procainamide + quinidine (CYP2D6 inhibitor) contraindicated: combo may incr. procainamide levels, risk of QT prolongation, cardiac arrhythmias, anticholinergic and other adverse effects (hepatic metab. inhibited, additive effects) thioridazine. procainamide (generic) +. WebbAlternatively, a loading dose of 20 mg/mL may be given via infusion at a rate of 1 mL/min over 25-30 minutes to deliver 500-600 mg of procainamide. Max: 1000 mg (given by either method). Maintenance to ensure therapeutic plasma concentrations: 2 mg/mL may be given at a rate of 1-3 mL/min; if total daily fluid intake must be decreased: 4 mg/mL ... trackmania turbo offer up
Procainamide for Wide Complex Tachycardia Pharmacology
WebbOral procainamide dosage forms are preferable for less urgent arrhythmias as well as for long-term maintenance after initial parenteral PA therapy. Intramuscular administration may be used as an alternative to the oral route for patients with less threatening arrhythmias but who are nauseated or vomiting, who are ordered to receive nothing by … WebbAlso, the dose should be reduced for patients with poor renal or cardiac rhythm. Pediatric Dosage of Procainamide. Now let's look at the pediatric dosage for procainamide. The initial dose of procainamide should be an infusion of 15mg/kg over a period of 30 to 60 minutes with continuous ECG monitoring and frequent blood pressure monitoring. WebbIf you miss a dose of Procainamide injection controlled-release, take it as soon as possible. If it is almost time for our next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use Procainamide injection controlled-release. the rock wine